conformational search software, low energy conformers, conformation analysis
About CONFLEX conformational search software CONFLEX conformational search software

CONFLEX Corporation provides conformation search and analysis software for examining the conformational space of small and large molecules. Identifying these conformers helps researchers in the selection of better quality leads during the discovery process. CONFLEX also includes algorithms for predicting IR, NMR, CD, and UV-Vis spectra.

CONFLEX also develops and licenses the CONFLEX Interface, a visualization and analysis platform especially designed for analysing CONFLEX outputs, e.g. conformational analyses, spectra output, and crystal packing, spectra, etc.

CONFLEX software products provide meaningful answers to both the expert computational chemist as well as the experimental and medicinal chemist investigating the role of molecular conformation. Designed for chemists by chemists, CONFLEX products exhibit high-accuracy, intuitive interfaces, and powerful command-line operation for interfacing with other modeling packages.

New features in CONFLEX 7 include Crystal Search and Optimization
Powder Diffraction Prediction, and the ability to run CONFLEX from ChemOffice products.
CONFLEX 7.0 Brochure

CONFLEX is introduced at the web site of 'Exploring Chemistry with Electronic Structure Methods' by Gaussian, Inc..
Conformational Searching with CONFLEX

Request a Fully Functional Trial of CONFLEX 7.


  • Calculate sum of interaction energies in hemispherical crystal
  • Performance improvement for crystal structure search (Parallel CONFLEX)
  • Change the definition of crystal energy
  • Support for MOL2 file format
  • Expanded torsion interaction
  • New keyword for fixed E-Z torsional configuration


CONFLEX More Info »

Conformation Analysis System. Unique capability to completely search the conformational space of a flexible molecule to find every optimal structure.

New Interface More Info »

The Visualization Interface for CONFLEX is now available for Mac, Windows, and Linux.

Consulting More Info »
Conformation Analysis Consulting using CONFLEX. An affordable alternative to licensing CONFLEX® software.

News & Events
American Chemical Society Exposition
San Diego, CA
Booth 215
March 13-15, 2016

News & Events
American Chemical Society Exposition
Philadelphia, PA
Booth 1116
August 21-23, 2016

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